Patient injecting Semaglutide

​At Prosper IV, we are committed to providing our clients with comprehensive and accurate information to support their health and wellness journeys. As part of our dedication to evidence-based practices, we aim to address common concerns regarding medications and their potential side effects. One such medication is semaglutide, a GLP-1 receptor agonist prescribed for type 2 diabetes management and chronic weight management. A frequently asked question is whether semaglutide causes fatigue. This article will explore the relationship between semaglutide and fatigue, drawing on current research and clinical insights.​

Understanding Semaglutide

Semaglutide mimics the action of the glucagon-like peptide-1 (GLP-1) hormone, which is essential in regulating blood sugar levels and appetite. By enhancing insulin secretion, suppressing glucagon release, and slowing gastric emptying, semaglutide helps control blood glucose and promotes weight loss. These mechanisms make it an effective treatment for individuals with type 2 diabetes and those looking for weight management solutions.

Semaglutide and Fatigue: What Does the Research Say?

Clinical trials and studies have reported fatigue as a potential side effect of semaglutide. The prevalence and severity of fatigue can vary based on the specific formulation and dosage:​

  • Wegovy (semaglutide 2.4 mg for weight management): Approximately 11% of participants reported experiencing fatigue during clinical trials.
  • Ozempic (semaglutide for type 2 diabetes): Fatigue was reported in less than 5% of participants.
  • Rybelsus (oral semaglutide): Fatigue was not commonly reported as a side effect in clinical trials.

Potential Causes of Fatigue

Several factors may contribute to the sensation of fatigue in individuals taking semaglutide:

  • Gastrointestinal Side Effects: Semaglutide commonly causes nausea, vomiting, and diarrhea. These can lead to dehydration and electrolyte imbalances, resulting in tiredness.
  • Caloric Intake Reduction: Semaglutide may suppress appetite and lead to decreased food consumption. This reduction in caloric intake can cause lower energy levels, manifesting as fatigue.
  • Blood Sugar Modulation: As semaglutide stabilizes blood glucose levels, some individuals might experience changes in energy levels during the body's adjustment period.

Managing Fatigue While on Semaglutide

If you are experiencing fatigue while taking semaglutide, consider the following strategies to manage and mitigate this side effect:​

  • Maintain Balanced Nutrition: Ensure you consume nutrient-dense meals that provide adequate energy. Even with reduced appetite, focus on foods rich in complex carbohydrates, proteins, and healthy fats.
  • Stay Hydrated: Adequate fluid intake is essential, especially if you are experiencing gastrointestinal side effects. Proper hydration can help alleviate feelings of fatigue. ​
  • Engage in Regular Physical Activity: Incorporate moderate exercise into your routine to boost energy levels and overall well-being.
  • Prioritize Quality Sleep: Establish a consistent sleep schedule and create a restful environment to improve sleep quality and reduce fatigue.
  • Consult Your Healthcare Provider: If fatigue persists or significantly impacts your daily life, discuss your symptoms with your healthcare provider. They may adjust your dosage or suggest additional interventions to manage this side effect.​

Why Choose prosperIV for Semaglutide Weight Loss Therapy?

At Prosper IV, we understand the importance of personalized care in managing side effects associated with medications like semaglutide. Our team is dedicated to supporting your health and wellness journey, providing tailored solutions to enhance your quality of life. If you have concerns about semaglutide or other treatments, we encourage you to contact our experienced healthcare professionals for guidance and support.​

If you’re ready to explore Semaglutide for weight loss, schedule a consultation with prosperIV today. Our team is here to support you on your journey to a healthier, more confident you.


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